After the sprinter's stage of the previous day, stage 5 will be a little more demanding and the puncheurs could come into their own. Apart from the last 35 kilometres, the section is not particularly difficult at first. After the turn-off from the coastal road, the route leads over wide roads towards Montescaglioso in the finale. A short and steep 4th category climb awaits the riders here, which should increase the tension in the race. A short descent is followed by a slightly ascending section that leads to Matera. The last three kilometres have it all again: a 10 per cent ramp leads into the city streets of Matera. First it goes downhill, then uphill again to the finish. Around one kilometre before the finish, the riders have to negotiate two left-hand bends, the first of which is particularly tight. The last 300 metres lead slightly uphill to the finish.
The profile of the 5th stage allows for various race scenarios. The last 35 kilometres with the climb to Montescaglioso and the demanding finale in Matera offer opportunities for breakaways and puncheurs. The finale is likely to be too demanding for the pure flatland sprinters. The 10 per cent ramp shortly before the finish could serve as a launch pad for a solo attack. The technically demanding finish with the two left-hand bends shortly before the end favours such a move. John Degenkolb won stage 5 of the 2013 Giro d'Italia in Matera in a similar manner. The German had broken away on the twisting last kilometre and saved a small lead to the finish.